Cambridge University spinout sign a 'major R&D partnership'

Kalium Health, a Cambridge University spinout developing the world’s first at-home blood potassium test, recently signed a major R&D partnership and has now gathered enough data to begin preparing for clinical evaluation.

Kalium is developing an integrated device-software platform that provides a rapid and quantitative electrolyte readout from just a single drop of blood. The company’s first target is accurate monitoring of potassium levels to improve the management of Chronic Kidney Disease (CKD).

Potassium balance in the body is critical and is normally regulated by the kidneys. However, people with CKD cannot effectively manage their potassium level so are at risk of imbalance, where potassium can build up in their body and reach dangerous levels without them knowing.

Currently, doctors require patients to attend clinical settings for regular, invasive blood draws but samples need laboratory analysis which makes real-time monitoring and timely treatment impossible. This is a major problem because high blood potassium levels (hyperkalaemia) can cause cardiac arrest.

Kalium Health recently agreed a major R&D partnership with Fresenius Medical Care, the world’s leading provider of products and services for people with CKD. The companies came together to integrate Kalium’s sensor technology into future kidney care products.

The company also recently celebrated the manufacture of 100,000 prototype tests, a major milestone that has enabled it to generate and analyse huge amounts of laboratory and pre-clinical data. This was essential to demonstrate that Kalium can manufacture reliably, at scale and at an unbeatable cost, and clears the path for the company’s next phase of clinical evaluation.

Evaluating Kalium’s technology with patients is a critical step towards regulatory approval. The company is now working with clinical partners to carry out studies demonstrating the technology in real-world settings. Following this, and in response to increasing demand at home and overseas, Kalium will complete validation activities leading to international regulatory approvals.

Kalium’s sensing technology uses 100 times less blood than traditional test methods and is pocket-sized and minimally-invasive, making it suitable for use by visiting nurses and patients themselves. Secure digital connectivity ensures the appropriate collection and sharing of data with Electronic Health Records.

The company is actively exploring new partnerships, particularly with US value-based kidney care providers and pharmaceutical companies conducting clinical trials of cardiorenal medications.

Tom Collings, CEO at Kalium Health, said “I am delighted with the advances in technology that we have made following our recent expansion and investment in upgraded facilities.

“We are pleased to have recently attracted the attention of major US investors who recognise the huge opportunity to provide remote monitoring of Chronic Kidney Disease, which affects 1 in 7 of the population and now consumes over 24 per cent of Medicare costs.”

By Mark Adair – Correspondent, Bdaily

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